抗病毒药物利巴韦林对亚急性硬化性全脑炎病毒的体外抑制作用。
In vitro inhibition of subacute sclerosing panencephalitis virus by the antiviral agent ribavirin.
作者信息
Murphy M F
出版信息
J Infect Dis. 1978 Aug;138(2):249-51. doi: 10.1093/infdis/138.2.249.
The multiplication in tissue cultures of three isolates of subacute sclerosing panencephalitis virus as well as the Edmonston strain of measles virus was observed to be inhibited by various concentrations of the antiviral agent ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide). The blockage of viral replication by ribavirin could be reversed by the simultaneous addition of equimolar concentrations of either guanosine or adenosine. Expression of virus-specific antigens was greatly reduced in the presence of the antiviral drug.
观察到亚急性硬化性全脑炎病毒的三个分离株以及麻疹病毒的埃德蒙斯顿株在组织培养中的增殖受到不同浓度抗病毒药物利巴韦林（1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺）的抑制。利巴韦林对病毒复制的阻断作用可通过同时添加等摩尔浓度的鸟苷或腺苷来逆转。在抗病毒药物存在的情况下，病毒特异性抗原的表达大大降低。
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