在接受抗病毒治疗及低剂量重组人粒细胞巨噬细胞集落刺激因子治疗的患者中，通过聚合酶链反应（PCR）对单核细胞和淋巴细胞中的艾滋病毒进行定量分析。
Quantification of HIV by PCR in monocytes and lymphocytes in patients receiving antiviral treatment and low dose recombinant human granulocyte macrophage colony stimulating factor.
作者信息
Davison F D, Kaczmarski R S, Pozniak A, Mufti G J, Sutherland S
机构信息
Virology Department, Dulwich Hospital, London.
出版信息
J Clin Pathol. 1994 Sep;47(9):855-7. doi: 10.1136/jcp.47.9.855.
Abstract
Neutropenia induced by antiviral treatment, in particular AZT, can be improved with recombinant human granulocyte macrophage colony stimulating factor (RHGMCSF) in HIV positive patients. However, there has been concern that this may increase the HIV load in the mononuclear cells of such patients. Five patients receiving AZT plus low dose RHGMCSF are reported. There was no consistent change in the levels of HIV DNA in the monocytes and lymphocytes. Additionally, all patients had stable disease with no opportunistic infection during the study period. It is concluded, therefore, that low dose RHGMCSF does not significantly change the viral DNA load in patients receiving AZT.
摘要
抗病毒治疗（尤其是齐多夫定）所致的中性粒细胞减少，可通过重组人粒细胞巨噬细胞集落刺激因子（RHGMCSF）在HIV阳性患者中得到改善。然而，有人担心这可能会增加此类患者单核细胞中的HIV载量。本文报道了5例接受齐多夫定加低剂量RHGMCSF治疗的患者。单核细胞和淋巴细胞中的HIV DNA水平没有持续变化。此外，所有患者在研究期间病情稳定，无机会性感染。因此得出结论，低剂量RHGMCSF不会显著改变接受齐多夫定治疗患者的病毒DNA载量。
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Quantification of HIV by PCR in monocytes and lymphocytes in patients receiving antiviral treatment and low dose recombinant human granulocyte macrophage colony stimulating factor.在接受抗病毒治疗及低剂量重组人粒细胞巨噬细胞集落刺激因子治疗的患者中，通过聚合酶链反应（PCR）对单核细胞和淋巴细胞中的艾滋病毒进行定量分析。
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