Koyanagi Y, O'Brien W A, Zhao J Q, Golde D W, Gasson J C, Chen I S
Department of Microbiology and Immunology, UCLA School of Medicine 90024.
Science. 1988 Sep 23;241(4873):1673-5. doi: 10.1126/science.241.4873.1673.
Some strains of human immunodeficiency virus type 1 (HIV-1) can infect primary monocytes and monocyte-derived macrophages in vitro. In this report, the effect of cytokines on the production of one of these strains that shows a tropism for mononuclear phagocytes, designated HIV-1JR-FL, was studied. Primary peripheral blood mononuclear phagocytes infected with HIV-1JR-FL were treated with the hematopoietic factors: granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), macrophage colony-stimulating factor (M-CSF), and gamma-interferon (gamma-IFN). The M-CSF, GM-CSF, IL-3, and gamma-IFN were able to alter HIV-1 production under different conditions.
某些1型人类免疫缺陷病毒（HIV-1）毒株能够在体外感染原代单核细胞和单核细胞衍生的巨噬细胞。在本报告中，研究了细胞因子对其中一种对单核吞噬细胞具有嗜性的毒株（命名为HIV-1JR-FL）产生的影响。用造血因子：粒细胞集落刺激因子（G-CSF）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素-3（IL-3）、巨噬细胞集落刺激因子（M-CSF）和γ干扰素（γ-IFN）处理感染了HIV-1JR-FL的原代外周血单核吞噬细胞。M-CSF、GM-CSF、IL-3和γ-IFN能够在不同条件下改变HIV-1的产生。
