Hattori N, Ishihara T, Saiwai S, Moridera K, Hino M, Ikekubo K, Kurahachi H
Department of Endocrinology, Kobe City General Hospital, Japan.
J Comput Assist Tomogr. 1994 Nov-Dec;18(6):936-8. doi: 10.1097/00004728-199411000-00017.
We present two patients with ectopic prolactinoma in the sphenoid sinus who were examined by MRI.
Endocrinological evaluations including spontaneous and drug-induced secretion of prolactin (PRL) and MRI features of two patients with ectopic prolactinoma were studied.
Both patients had elevated serum PRL levels, and the endocrinological evaluations were similar to those in ectopic prolactinoma. Magnetic resonance of the head revealed a mass occupying the sphenoid sinus with partially empty sella in Case 1 and with normal pituitary gland in Case 2. Ectopic PRL secretion was confirmed by immunocytochemical examination of the ectopic tumor. Case 1 was treated with bromocriptine, leading to marked decrease in serum PRL levels and reduction of tumor size. Transsphenoidal surgery was performed in Case 2, resulting in normalization of serum PRL levels.
It is necessary to consider ectopic prolactinoma for the differential diagnosis of the sphenoid sinus tumors.
我们报告两例蝶窦异位泌乳素瘤患者，均接受了磁共振成像（MRI）检查。
研究了两例异位泌乳素瘤患者的内分泌学评估，包括泌乳素（PRL）的自发分泌和药物诱导分泌以及MRI特征。
两名患者血清PRL水平均升高，内分泌学评估结果与异位泌乳素瘤患者相似。头部磁共振成像显示，病例1中蝶窦有占位性病变，伴有部分空蝶鞍；病例2中垂体正常。通过对异位肿瘤的免疫细胞化学检查证实了异位PRL分泌。病例1接受溴隐亭治疗，血清PRL水平显著下降，肿瘤大小减小。病例2接受了经蝶窦手术，血清PRL水平恢复正常。
对于蝶窦肿瘤的鉴别诊断，有必要考虑异位泌乳素瘤。
