恶性颗粒细胞瘤。

Malignant granular cell tumor.

作者信息

Gokaslan S T, Terzakis J A, Santagada E A

机构信息

Department of Pathology, Lenox Hill Hospital, New York, N.Y. 10021.

出版信息

J Cutan Pathol. 1994 Jun;21(3):263-70. doi: 10.1111/j.1600-0560.1994.tb00271.x.

DOI:10.1111/j.1600-0560.1994.tb00271.x

PMID:7962829

Abstract

We report a case of malignant granular cell tumor present in the left medial mid-thigh of a 69-year-old black male. The lesion was grossly fungating, partially ulcerated and measured 14 cm in largest diameter. Light microscopy, electron microscopy and immunohistochemistry techniques were used to confirm the preliminary cytologic diagnosis of malignant granular cell tumor. Diagnostic criteria of malignancy for such lesions are reviewed. Immunohistochemical and ultrastructural analyses support a neural or Schwann cell origin for the tumor. Clinical outcome for such lesions is discussed.

摘要

我们报告一例69岁黑人男性左大腿中部内侧的恶性颗粒细胞瘤。该病变肉眼可见呈蕈状，部分溃疡，最大直径为14厘米。运用光镜、电镜及免疫组化技术来证实恶性颗粒细胞瘤的初步细胞学诊断。回顾了此类病变的恶性诊断标准。免疫组化和超微结构分析支持该肿瘤起源于神经或施万细胞。讨论了此类病变的临床结局。