Abraham Z, Glück Z, Kinarty A, Lahat N
Department of Dermatology, Reish Policlinic, Haifa, Israel.
J Dermatol. 1994 Aug;21(8):590-4. doi: 10.1111/j.1346-8138.1994.tb01799.x.
Paget's bone disease developed in a patient with vitiligo. Scrupulous physical examination excluded further systemic or cutaneous involvement. The immunological workup revealed a reversed CD4/CD8 ratio due to a very low CD4 cell percentage and almost negligible responses to PHA as well as Con A, T cell mitogens. The pathogenic significance of these results, which point to phenotypic and functional T cell defects, is discussed.
一名白癜风患者患上了佩吉特骨病。细致的体格检查排除了进一步的全身或皮肤受累情况。免疫检查显示，由于CD4细胞百分比极低，以及对PHA和Con A（T细胞有丝分裂原）的反应几乎可以忽略不计，CD4/CD8比值倒置。本文讨论了这些表明T细胞表型和功能缺陷的结果的致病意义。
