Katayama I, Yokozeki H, Nishioka K
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
J Dermatol. 1994 Aug;21(8):604-8. doi: 10.1111/j.1346-8138.1994.tb01802.x.
Three cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50-100 mg/day). The clinical effect first appeared at 2 weeks after the initiation of therapy and no recurrence was observed for more than 3 months without minocycline. Gram positive cocci were demonstrated inside the hair follicle and horny layers in all 4 case. Minocycline might modulate abberant keratinization through its bactericidal effects in these keratinizing disorders.
3例毛囊性鱼鳞病（土肥）和1例融合性网状乳头瘤病患者口服米诺环素（50 - 100毫克/天）治疗成功。临床疗效在治疗开始后2周首次出现，停用米诺环素后3个月以上未观察到复发。所有4例患者的毛囊和角质层内均发现革兰氏阳性球菌。米诺环素可能通过其在这些角化性疾病中的杀菌作用来调节异常角化。
