Ozdemirler G, Aykaç G, Uysal M, Oz H
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
J Appl Toxicol. 1994 Jul-Aug;14(4):297-9. doi: 10.1002/jat.2550140410.
Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg-1 i.p.). Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities. In this way, these glutathione-related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.
在对乙酰氨基酚治疗（腹腔注射500mg/kg）6小时后，发现全肝匀浆中的谷胱甘肽水平降低，而脂质过氧化物水平升高。此外，已确定胞质谷胱甘肽S-转移酶（GST）活性降低，谷胱甘肽过氧化物酶（GSH-Px）活性保持不变。另一方面，观察到肝微粒体脂质过氧化物水平降低，GST和GSH-Px活性增加。我们得出结论，微粒体中脂质过氧化物水平降低可能是GSH-Px和GST酶活性增加的结果。通过这种方式，这些与谷胱甘肽相关的防御酶系统可能在保护微粒体免受脂质过氧化方面发挥重要作用。
