Adhikari P, Haldar S, Ghosh N R, Mandal M M, Haldar J P
Department of Physiology, Suri Vidyasagar College, West Bengal.
J Commun Dis. 1994 Mar;26(1):6-13.
The present study reports results of a survey of bancroftian filariasis in Burdwan district West Bengal. 85,974 persons were examined of which 46,221 were inhabitants of the colliery areas of the district and rest 39,753 were from non-Colliery areas, including urban and rural areas of the district. The clinicopositivity, endemicity, microfilaria(mf)-positivity, mf-clinicopositivity, and mf-density were determined. It was found that all these epidemiological and parasitological parameters were significantly higher in the colliery area as compared to non-colliery area. The high vector density in the colliery area may account for such significantly higher prevalence of filariasis in this area. From a differential count of neutrophils, eosinophils and lymphocytes in the mf-positive cases, it was revealed that neutrophil percentage was significantly (P < 0.01) decreased while eosinophils and Lymphocytes increased. The decrease of neutrophils was correlated ((Correlation co-efficient, r = -0.78) with the increase of lymphocytes, indicating an imbalance in the immune-system of the infected persons. The geographical and geological factors resulting in high vector density are considered responsible for the significantly higher rate of bancroftian filariasis in the Colliery area.
本研究报告了西孟加拉邦布尔杜万地区班氏丝虫病的调查结果。共检查了85974人，其中46221人是该地区煤矿区居民，其余39753人来自非煤矿区，包括该地区的城乡地区。测定了临床阳性率、流行率、微丝蚴（mf）阳性率、mf临床阳性率和mf密度。结果发现，与非煤矿区相比，煤矿区所有这些流行病学和寄生虫学参数均显著更高。煤矿区媒介密度高可能是该地区丝虫病患病率显著更高的原因。对mf阳性病例的中性粒细胞、嗜酸性粒细胞和淋巴细胞进行分类计数后发现，中性粒细胞百分比显著降低（P<0.01），而嗜酸性粒细胞和淋巴细胞增加。中性粒细胞的减少与淋巴细胞的增加相关（相关系数，r=-0.78），表明感染者免疫系统失衡。导致媒介密度高的地理和地质因素被认为是煤矿区班氏丝虫病发病率显著更高的原因。
