Suzuki I, Oho K, Nakayama S, Tamura K, Tsuboi M, Okitsu H
Ohfuna Central Hospital, Kanagawa, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Aug;42(8):1208-13.
We report a rare case of pulmonary blastoma. This 59-year-old woman has been apparently well with recurrent and metastatic tumors in her left lung for 9 years after the initial operation. On May 28, 1984, she underwent a thoracotomy of left upper lobectomy and lymph nodes dissection. The histologic diagnosis of resected specimen was pulmonary blastoma. In August 1986 (27 months after the initial surgery), chest X-ray revealed some nodules in the lungs. Then, the patient had two thoracotomies for the excision of 4 tumors and one chest wall resection of the tumor. In addition, she received systemic chemotherapy 28 times, directly intrapulmonary drug injection 3 times and radiation therapy once for recurrent and metastatic disease. Following some cycles of our combination chemotherapy consisting of cis-platinum and vindesine, some lesions had decreased in size and others previously seen on chest X-ray were no longer evident. She achieved an objective response with receiving two-drug chemotherapy. Our observation suggest that this intensive combination chemotherapy is effective in recurrent and metastatic disease of pulmonary blastoma as a surgical adjuvant.
我们报告一例罕见的肺母细胞瘤病例。这位59岁女性在初次手术后，左肺出现复发和转移性肿瘤，情况良好达9年。1984年5月28日，她接受了左上叶肺切除术及淋巴结清扫术。切除标本的组织学诊断为肺母细胞瘤。1986年8月（初次手术后27个月），胸部X线显示肺部有一些结节。随后，患者接受了两次开胸手术以切除4个肿瘤，以及一次胸壁肿瘤切除术。此外，她因复发和转移性疾病接受了28次全身化疗、3次肺内直接药物注射和1次放射治疗。在我们采用顺铂和长春地辛联合化疗的几个周期后，一些病灶尺寸减小，其他之前在胸部X线可见的病灶不再明显。她接受两药化疗后获得了客观缓解。我们的观察表明，这种强化联合化疗作为手术辅助手段，对肺母细胞瘤的复发和转移性疾病有效。
