Noordsy D L, Drake R E, Biesanz J C, McHugo G J
New Hampshire-Dartmouth Psychiatric Research Center, Concord 03301.
J Nerv Ment Dis. 1994 Nov;182(11):651-5. doi: 10.1097/00005053-199411000-00009.
Previous research has shown that family history of alcoholism (FHA) is associated with several aspects of the development and expression of alcohol use disorder in people who are not mentally ill. This study examined FHA in a group of 66 schizophrenic outpatients who were well characterized in terms of their alcohol use and were followed prospectively in treatment for 4 years. The FHA-positive probands (42.4% of the group) were more likely to have alcohol use disorder. Contrary to our prediction, the relationship between FHA and alcoholism in the probands was significant for women but not for men. Among schizophrenic probands with alcoholism, positive FHA was associated with more severe alcoholism and with the use of other drugs. Probands with positive FHA also responded less well to alcoholism treatment than did probands with negative FHA. These exploratory findings have significant implications for understanding risk, for conducting assessment, and for studying treatment, but should be confirmed in larger and more representative samples of people with schizophrenia.
先前的研究表明，酗酒家族史（FHA）与非精神疾病患者酒精使用障碍的发生和表现的多个方面相关。本研究对一组66名精神分裂症门诊患者的酗酒家族史进行了调查，这些患者在酒精使用方面特征明确，并接受了为期4年的前瞻性治疗随访。FHA阳性的先证者（占该组的42.4%）更有可能患有酒精使用障碍。与我们的预测相反，先证者中FHA与酗酒之间的关系在女性中显著，而在男性中不显著。在患有酒精使用障碍的精神分裂症先证者中，FHA阳性与更严重的酒精使用障碍以及其他药物的使用相关。FHA阳性的先证者对酒精使用障碍治疗的反应也比FHA阴性的先证者差。这些探索性发现对理解风险、进行评估和研究治疗具有重要意义，但应在更大且更具代表性的精神分裂症患者样本中得到证实。
