Tosios K, Koutlas I G, Papanicolaou S I
Department of Oral Pathology and Surgery, Faculty of Dentistry, University of Athens, Greece.
J Oral Maxillofac Surg. 1994 Dec;52(12):1263-8. doi: 10.1016/0278-2391(94)90048-5.
Intravascular papillary endothelial hyperplasia (IPEH) is a benign, nonneoplastic, vascular lesion, that is characterized histologically by papillary fronds lined by proliferating endothelium: it is thought to represent an unusual form of organizing thrombus. It may develop in a distended vessel or in association with other vascular lesions. The main significance of IPEH is its microscopic resemblance to angiosarcoma and possible misinterpretation as such.
We report the clinicopathologic features of 18 examples of IPEH of the oral soft tissues and lips, and review such features of 55 previously reported oral cases.
The lips and tongue were most frequently involved and a female predilection was evident. Histologically, the pure form of IPEH was more commonly encountered.
The differential diagnosis and possible histogenesis of the lesion are discussed.
血管内乳头状内皮增生（IPEH）是一种良性、非肿瘤性血管病变，其组织学特征为有增生内皮细胞衬里的乳头状叶：它被认为是机化血栓的一种特殊形式。它可发生于扩张的血管内或与其他血管病变相关。IPEH的主要意义在于其在显微镜下与血管肉瘤相似，可能会被误诊为此病。
我们报告了18例口腔软组织和唇部IPEH的临床病理特征，并回顾了55例先前报道的口腔病例的此类特征。
唇部和舌部最常受累，且明显以女性居多。组织学上，IPEH的纯形式更常见。
讨论了该病变的鉴别诊断及可能的组织发生。
