生长调节素C（胰岛素样生长因子1）水平在应激相关激素急性变化期间降低。与纤维肌痛的相关性。
Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia.
作者信息
Ferraccioli G, Guerra P, Rizzi V, Baraldo M, Salaffi F, Furlanut M, Bartoli E
机构信息
Institute of Internal Medicine, Chair of Clinical Pharmacology, School of Medicine, Udine, Italy.
出版信息
J Rheumatol. 1994 Jul;21(7):1332-4.
OBJECTIVE
To determine the effects of stress hormones on insulin-like growth factor 1 (IGF-1).
METHODS
Insulin induced hypoglycemia (< 3 mmol/l) and clonidine induced depression of noradrenergic tone were used to assess the acute effects of cortisol, human growth hormone (hGH), and norepinephrine (NE).
RESULTS
Despite the increase of hGH during hypoglycemia, a statistically significant decrease of IGF-1 was observed along with the expected rise of cortisol and NE. To eliminate the role played by NE, NE tone was depressed by administering clonidine. A statistically significant decrease of IGF-1 was also observed.
CONCLUSION
Acute cortisol release or a NE decrease induce low IGF-1 levels.
目的
确定应激激素对胰岛素样生长因子1（IGF-1）的影响。
方法
采用胰岛素诱导低血糖（<3 mmol/L）和可乐定诱导去甲肾上腺素能张力降低，以评估皮质醇、人生长激素（hGH）和去甲肾上腺素（NE）的急性作用。
结果
尽管低血糖期间hGH增加，但观察到IGF-1有统计学意义的下降，同时皮质醇和NE如预期升高。为消除NE的作用，通过给予可乐定降低NE张力。也观察到IGF-1有统计学意义的下降。
结论
急性皮质醇释放或NE减少会导致IGF-1水平降低。
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