Ferraccioli G, Guerra P, Rizzi V, Baraldo M, Salaffi F, Furlanut M, Bartoli E
Institute of Internal Medicine, Chair of Clinical Pharmacology, School of Medicine, Udine, Italy.
J Rheumatol. 1994 Jul;21(7):1332-4.
To determine the effects of stress hormones on insulin-like growth factor 1 (IGF-1).
Insulin induced hypoglycemia (< 3 mmol/l) and clonidine induced depression of noradrenergic tone were used to assess the acute effects of cortisol, human growth hormone (hGH), and norepinephrine (NE).
Despite the increase of hGH during hypoglycemia, a statistically significant decrease of IGF-1 was observed along with the expected rise of cortisol and NE. To eliminate the role played by NE, NE tone was depressed by administering clonidine. A statistically significant decrease of IGF-1 was also observed.
Acute cortisol release or a NE decrease induce low IGF-1 levels.
确定应激激素对胰岛素样生长因子1（IGF-1）的影响。
采用胰岛素诱导低血糖（<3 mmol/L）和可乐定诱导去甲肾上腺素能张力降低，以评估皮质醇、人生长激素（hGH）和去甲肾上腺素（NE）的急性作用。
尽管低血糖期间hGH增加，但观察到IGF-1有统计学意义的下降，同时皮质醇和NE如预期升高。为消除NE的作用，通过给予可乐定降低NE张力。也观察到IGF-1有统计学意义的下降。
急性皮质醇释放或NE减少会导致IGF-1水平降低。
