Hansen D K, Grafton T F
Department of Health and Human Services, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502.
J Toxicol Environ Health. 1994 Nov;43(3):361-7. doi: 10.1080/15287399409531927.
Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer. Human exposure has been documented, and therefore it is important to investigate the toxic potential of this compound. When DEHP was administered in vivo, it was found to be a developmental toxicant in rodents. The purpose of this investigation was to determine if DEHP was directly embryotoxic to rat embryos. Embryos were cultured for 44 h beginning on gestational d 10. Embryos were cultured in rat serum to which DEHP was added to attain final concentrations within the 0.01-2.0% range. DEHP decreased growth and development at all tested concentrations higher than 0.5%. These results suggest that the parent compound itself is able to alter normal embryonic growth and development; however the high embryotoxic concentrations are unlikely to be attained in vivo.
邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种常用的增塑剂。已有人类接触该物质的记录，因此研究这种化合物的潜在毒性很重要。当DEHP进行体内给药时，发现它对啮齿动物具有发育毒性。本研究的目的是确定DEHP是否对大鼠胚胎具有直接胚胎毒性。胚胎从妊娠第10天开始培养44小时。胚胎在添加了DEHP的大鼠血清中培养，以使最终浓度达到0.01 - 2.0%的范围。在所有高于0.5%的测试浓度下，DEHP均降低了生长和发育。这些结果表明母体化合物本身能够改变正常的胚胎生长和发育；然而，在体内不太可能达到高胚胎毒性浓度。
