Lewis D E, Moore C M, Leikin J B
United States Drug Testing Laboratories, Chicago, Illinois.
J Toxicol Clin Toxicol. 1994;32(6):697-703. doi: 10.3109/15563659409017976.
Cocaethylene, a metabolite of cocaine and ethanol, exhibits cardiac and neurobehavioral effects. In order to determine the prevalence of this compound in meconium specimens, samples which gave a positive result for benzoylecgonine using fluorescence polarization immunoassay were analyzed by gas chromatography/mass spectrometry for cocaine, cocaethylene and benzoylecgonine. Deuterated cocaine, cocaethylene and benzoylecgonine were used as internal standards. Gas chromatography/mass spectrometry cutoff concentrations of 5.0 ng/g were utilized for all analytes. Of the 361 specimens which consecutively confirmed positive for cocaine or benzoylecgonine, 114 (31.6%) tested positive for cocaethylene. Further, cocaethylene accumulates in greater concentrations in meconium than urine, and is a useful analyte for identifying fetal alcohol exposure.
古柯乙烯是可卡因和乙醇的一种代谢产物，具有心脏和神经行为效应。为了确定该化合物在胎粪样本中的流行情况，对使用荧光偏振免疫分析法检测苯甲酰爱康宁呈阳性的样本进行气相色谱/质谱分析，以检测可卡因、古柯乙烯和苯甲酰爱康宁。氘代可卡因、古柯乙烯和苯甲酰爱康宁用作内标。所有分析物的气相色谱/质谱截止浓度均为5.0纳克/克。在361份连续检测可卡因或苯甲酰爱康宁呈阳性的样本中，114份（31.6%）古柯乙烯检测呈阳性。此外，古柯乙烯在胎粪中的积累浓度高于尿液，是识别胎儿酒精暴露的一种有用分析物。
