Stephens F D, Gupta D
Royal Children's Hospital, Melbourne, Australia.
J Urol. 1994 Dec;152(6 Pt 2):2328-31. doi: 10.1016/s0022-5347(17)31669-5.
The triad of abnormalities of the prune belly syndrome may arise simply from the effects of early urethral obstruction or alternatively from a basic defect of the mesoderm from which the triad of abnormalities develops. The urethra and genital tract of 21 prune belly syndrome specimens and 23 specimens of Young's posterior urethral valves types 1 and 3 were compared in a study for differences in the pathological anatomy that may elucidate the controversy. The specimens were dissected and investigated radiographically and histologically. The seminal ducts and vesicles, and prostatic glands were abnormal in the prune belly syndrome specimens and normally developed in the posterior urethral valve specimens. We contest that this major difference stems from a primary defect of the intermediate and lateral plate mesoderm in the prune belly syndrome which would affect the embryogenesis not only of the mesonephric and paramesonephric ducts but also of the musculature of the abdominal wall and urinary organs, and that prune belly valves when present are intrinsic components of the mesodermal defect of the prune belly syndrome urethra.
梅干腹综合征的三联征异常可能仅仅源于早期尿道梗阻的影响，或者源于中胚层的基本缺陷，三联征异常由此发展而来。在一项旨在阐明争议的研究中，对21例梅干腹综合征标本以及23例1型和3型杨氏后尿道瓣膜标本的尿道和生殖道进行了比较，以研究可能存在的病理解剖差异。对标本进行了解剖，并进行了放射学和组织学检查。梅干腹综合征标本中的输精管、精囊和前列腺异常，而后尿道瓣膜标本中的这些结构发育正常。我们认为，这一主要差异源于梅干腹综合征中侧板和侧板中胚层的原发性缺陷，这不仅会影响中肾管和副中肾管的胚胎发育，还会影响腹壁和泌尿器官的肌肉组织，并且梅干腹瓣膜（若存在）是梅干腹综合征尿道中胚层缺陷的固有组成部分。
