Lemkina S M
Kardiologiia. 1993;33(5):37-40.
Two models of heart failure were used in rat experiments to study the effect of isoptin on tolerance to the toxic effect of k-strophanthin. Calcium antagonist-induced changes in the cardiotonic and chronotropic effects of the cardiac glycoside and myocardial oxygen consumption were examined in isolated frog atria with a movable-electrode electron tube and polarography. Isoptin was shown to substantially enhance tolerance to the toxic effect of k-strophanthin and slightly decrease positive inotropic effects of the cardiotonic, by slowing down its development rate. The agent potentiated the negative chronotropic action and lowered myocardial oxygen consumption.
在大鼠实验中使用了两种心力衰竭模型，以研究异搏定对毒毛花苷 K 毒性作用耐受性的影响。用活动电极电子管和极谱法在离体蛙心房中检测钙拮抗剂诱导的强心苷的强心和变时作用以及心肌耗氧量的变化。结果表明，异搏定可通过减缓强心作用的发展速度，显著增强对毒毛花苷 K 毒性作用的耐受性，并略微降低强心苷的正性肌力作用。该药物增强了负性变时作用并降低了心肌耗氧量。
