Asensio A J, Besses C, Palacín A, Sans-Sabrafen J
Laboratorio de Hematología, Hospital Comarcal Sant Camil, Sant Pere de Ribes, Barcelona.
Med Clin (Barc). 1994 Sep 24;103(9):339-41.
The cases of three patients with primary testicular lymphoma, Ann Arbor IAE stage with the ages of 74, 72 and 60 years are presented. Histologic results demonstrated 2 cases of intermediate grade of malignancy and 1 of low grade. Immunohistochemical analysis for epithelial antigens was negative and the measurement of the serum levels of alpha-fetoprotein and beta-HCG was normal. LDH and beta-2-microglobulin were also normal. Chemotherapy was performed and the three patients remain alive and free of disease at 65, 32 and 19 months following diagnosis. The therapeutic results of the most important series were reviewed with the conclusion that treatment should be intensive, including orchiectomy plus chemotherapy even in apparently localized cases. The complementary role of radiotherapy is also discussed.
本文报告了3例原发性睾丸淋巴瘤患者的病例，Ann Arbor分期均为IAE期，年龄分别为74岁、72岁和60岁。组织学结果显示，2例为中度恶性，1例为低度恶性。上皮抗原的免疫组化分析为阴性，血清甲胎蛋白和β-HCG水平测定正常。乳酸脱氢酶（LDH）和β2微球蛋白也正常。进行了化疗，3例患者在诊断后65个月、32个月和19个月时仍存活且无疾病。回顾了最重要系列研究的治疗结果，得出的结论是，即使在明显局限的病例中，治疗也应强化，包括睾丸切除术加化疗。还讨论了放疗的辅助作用。
