美国HIV抗体检测对HIV-1 O组感染的检测敏感性。

Sensitivity of United States HIV antibody tests for detection of HIV-1 group O infections.

作者信息

Schable C, Zekeng L, Pau C P, Hu D, Kaptue L, Gurtler L, Dondero T, Tsague J M, Schochetman G, Jaffe H

机构信息

Division of HIV/AIDS, National Centre for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.

出版信息

Lancet. 1994 Nov 12;344(8933):1333-4. doi: 10.1016/s0140-6736(94)90695-5.

DOI:10.1016/s0140-6736(94)90695-5

PMID:7968029

Abstract

Infections by highly divergent strains of HIV-1, first detected in central Africa and grouped provisionally as group O, have not been reliably detected by certain European HIV screening tests. Serum specimens from eight probable group O infections from Cameroon were tested by ten HIV assays licensed by the US Food and Drug Administration. All assays based on synthetic peptides or recombinant antigens failed to detect at least one of the infections; assays based on whole-virus lysates performed better. Divergent HIV strains may be undetected by current HIV tests. Thus active surveillance for and characterisation of HIV variants to evaluate and, when necessary, modify current tests is urgently needed.

摘要

在中非首次检测到的高度分化的HIV-1毒株感染，最初被临时归类为O组，某些欧洲HIV筛查检测未能可靠地检测到这些感染。来自喀麦隆的8例可能为O组感染的血清标本，通过美国食品药品监督管理局批准的10种HIV检测方法进行检测。所有基于合成肽或重组抗原的检测方法至少未能检测到其中1例感染；基于全病毒裂解物的检测方法表现更好。当前的HIV检测可能无法检测到分化的HIV毒株。因此，迫切需要对HIV变异株进行主动监测和特征分析，以评估并在必要时修改当前的检测方法。