萘基甲基取代四氢异喹啉YS 49对大鼠和家兔的心血管作用
Cardiovascular effect of a naphthylmethyl substituted tetrahydroisoquinoline, YS 49, in rat and rabbit.
作者信息
Lee Y S, Kim C H, Yun-Choi H S, Chang K C
机构信息
Department of Pharmacology, College of Medicine, Gyeongsang National University, Chinju, Korea.
出版信息
Life Sci. 1994;55(21):PL415-20. doi: 10.1016/0024-3205(94)00335-1.
A novel tetrahydroisoquinoline, 1-alpha-naphthylmethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline (YS 49) 1) increased heart rate and force in isolated rat atria; 2) relaxed PE- and KCl-contracted rat aorta, and 3) decreased blood pressure and increased heart rate in anesthetized rabbit. These effects were blocked by propranolol, a nonselective beta-antagonist, but not by phentolamine, an alpha-blocker, and/or depletion of catecholamine by reserpine. These results suggest that the mechanism of action of YS 49 is due, at least in part, to beta-adrenergic receptor stimulation.
一种新型四氢异喹啉，1-α-萘甲基-6,7-二羟基-1,2,3,4-四氢异喹啉（YS 49）：1）可使离体大鼠心房的心率和收缩力增加；2）使去甲肾上腺素和氯化钾收缩的大鼠主动脉松弛；3）使麻醉兔的血压降低、心率增加。这些作用被非选择性β受体拮抗剂普萘洛尔阻断，但未被α受体阻滞剂酚妥拉明和/或利血平使儿茶酚胺耗竭所阻断。这些结果表明，YS 49的作用机制至少部分是由于刺激β肾上腺素能受体所致。
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