将人骨肉瘤植入裸鼠体内后，用31P变化作为治疗反应的一种衡量指标。

31P changes as a measure of therapy response in human osteosarcomas implanted into nude mice.

作者信息

Kang H, Ballinger J R, Sweeney C, Croker B P, Scott K N

机构信息

Department of Radiology, University of Florida, Gainesville 32610.

出版信息

Magn Reson Imaging. 1994;12(6):935-43. doi: 10.1016/0730-725x(94)92034-6.

DOI:10.1016/0730-725x(94)92034-6

PMID:7968292

Abstract

Our objective was to determine whether changes in PME and PCr/Pi can be used to predict lack of tumor response to chemotherapy in a murine model of human osteosarcoma. A chemotherapy-sensitive human osteosarcoma cell line was implanted into the flank of 22 nude mice. Cisplatin was administered to 11 of the mice 9 days postimplantation. 31P MR spectroscopy was performed pre- and post-chemotherapy in both sets of mice. Statistically significant changes in PCr/Pi occur from post-chemotherapy in the treated mice, but not in the untreated mice during the same time. Change in PME parallels changes in tumor volume. Changes in PCr/Pi predict lack of chemotherapy treatment in human osteosarcoma implanted into nude mice with a specificity of 80% and a sensitivity of 63%. The change in PCr/Pi occurs prior to any changes in volume of the tumor [corrected].

摘要

我们的目的是确定在人骨肉瘤小鼠模型中，磷酸单酯（PME）和磷酸肌酸/无机磷（PCr/Pi）的变化是否可用于预测肿瘤对化疗无反应。将一种对化疗敏感的人骨肉瘤细胞系植入22只裸鼠的胁腹。在植入后9天，对11只小鼠给予顺铂。两组小鼠在化疗前后均进行了磷-31磁共振波谱分析。化疗后，治疗组小鼠的PCr/Pi发生了统计学上的显著变化，而同期未治疗组小鼠未出现这种变化。PME的变化与肿瘤体积的变化平行。PCr/Pi的变化可预测植入裸鼠的人骨肉瘤对化疗无反应，特异性为80%，敏感性为63%。PCr/Pi的变化发生在肿瘤体积出现任何变化之前[校正后]。