Luoto R, Rutanen E M, Kaprio J
University of Helsinki, Department of Public Health, Finland.
Maturitas. 1994 Aug;19(2):141-52. doi: 10.1016/0378-5122(94)90064-7.
Trends in hospitalizations for selected gynecologic diagnoses per 100,000 women/year associated with hysterectomy were analyzed using the Finnish hospital discharge register data, including each inpatient episode in all Finnish hospitals, from 1971 to 1986. The diagnoses selected were uterine leiomyoma, genital prolapse, the group 'other disorders of the uterus' including endometriosis, and bleeding disorders. These were the most common indications for hysterectomy in Finland from 1987 to 1989, when national data on surgical procedures were included in the hospital discharge register. Trends in the incidence of hospitalizations for malignant neoplasms were also analyzed, although < 10% of hysterectomies are due to gynecological malignancies. Hospitalizations for leiomyoma, endometriosis and bleeding disorders have statistically increased, significantly, among women aged 45 years or more between 1971 and 1986, whereas hospitalizations for prolapse and malignant neoplasms did not show a significant change. Probable incidence of hysterectomy before 1986 was estimated on the basis of the annual incidence of hospitalization for leiomyoma, and hysterectomy for leiomyomas was estimated from the hospital discharge register data of 1988. According to hospital discharge data in 1988, 90% of the hospitalized women with leiomyoma underwent hysterectomy and half of the hysterectomies were performed for leiomyoma. The estimated incidence of hysterectomy increased from 311/100,000 women to approximately 400/100,000 from 1971 to 1986 (slope = 6.5 hysterectomies/100,000/year; 95% C.I. for slope (4.8:8.2)). As the epidemiology of most of the underlying disorders for indications leading to hysterectomy is poorly known, epidemiological studies should consider the determinants of the occurrence of indications independently whether hysterectomy has been performed or not.
利用芬兰医院出院登记数据,对1971年至1986年期间每10万名女性/年与子宫切除术相关的特定妇科诊断的住院趋势进行了分析,数据包括芬兰所有医院的每一次住院病例。所选诊断包括子宫平滑肌瘤、生殖器脱垂、包括子宫内膜异位症在内的“子宫其他疾病”组以及出血性疾病。这些是1987年至1989年芬兰子宫切除术最常见的指征,当时手术程序的国家数据被纳入医院出院登记。尽管子宫切除术<10%是由于妇科恶性肿瘤,但也分析了恶性肿瘤住院发生率的趋势。1971年至1986年期间,45岁及以上女性中平滑肌瘤、子宫内膜异位症和出血性疾病的住院率在统计学上显著增加,而脱垂和恶性肿瘤的住院率没有显著变化。根据平滑肌瘤住院的年发生率估计了1986年前子宫切除术的可能发生率,并根据1988年医院出院登记数据估计了平滑肌瘤的子宫切除术。根据1988年医院出院数据,90%的平滑肌瘤住院女性接受了子宫切除术,其中一半的子宫切除术是针对平滑肌瘤进行的。1971年至1986年期间,子宫切除术的估计发生率从每10万名女性311例增加到约400例(斜率=6.5例子宫切除术/10万/年;斜率的95%置信区间(4.8:8.2))。由于导致子宫切除术指征的大多数潜在疾病的流行病学情况鲜为人知,流行病学研究应独立考虑指征发生的决定因素,无论是否进行了子宫切除术。