Parte A C, Smith J T
Department of Pharmaceutics, School of Pharmacy, University of London, Great Britain.
Microbios. 1994;79(319):87-95.
The bactericidal activities of the 4-quinolones ciprofloxacin and levofloxacin against Staphylococcus aureus and Staphylococcus epidermidis in nutrient broth were dramatically reduced when the temperature of incubation was decreased from 37 to 20 degrees C. For S. aureus the relative reduction in the activities was 86- and 46-fold with ciprofloxacin or levofloxacin, respectively. For S. epidermidis the corresponding reduction in activities was 82- and 19-fold, respectively. At infectious sites which are at lower-than-body temperature the reduced activity of 4-quinolones may contribute to clinical failure and/or the development of resistance. Levofloxacin was more bactericidal than ciprofloxacin against either of the staphylococci at every temperature tested. These results tend to suggest that levofloxacin may be preferable to ciprofloxacin for staphylococcal infections especially at skin and soft-tissue sites.
当培养温度从37℃降至20℃时，营养肉汤中4-喹诺酮类药物环丙沙星和左氧氟沙星对金黄色葡萄球菌和表皮葡萄球菌的杀菌活性显著降低。对于金黄色葡萄球菌，环丙沙星或左氧氟沙星的活性相对降低倍数分别为86倍和46倍。对于表皮葡萄球菌，活性的相应降低倍数分别为82倍和19倍。在低于体温的感染部位，4-喹诺酮类药物活性降低可能导致临床治疗失败和/或耐药性的产生。在每个测试温度下，左氧氟沙星对两种葡萄球菌的杀菌作用均强于环丙沙星。这些结果表明，对于葡萄球菌感染，尤其是皮肤和软组织部位的感染，左氧氟沙星可能比环丙沙星更具优势。
