狂犬病病毒减毒RC-HL株的糖蛋白基因发生独特突变，该毒株是日本用于生产动物疫苗的种毒。
A unique mutation of glycoprotein gene of the attenuated RC-HL strain of rabies virus, a seed virus used for production of animal vaccine in Japan.
作者信息
Ito H, Minamoto N, Watanabe T, Goto H, Rong L T, Sugiyama M, Kinjo T, Mannen K, Mifune K, Konobe T
机构信息
Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, Japan.
出版信息
Microbiol Immunol. 1994;38(6):479-82. doi: 10.1111/j.1348-0421.1994.tb01812.x.
Although the RC-HL strain of rabies virus is avirulent in adult mice, the amino acid at position 333 of its G protein is arginine, which is thought to be necessary for virulence in adult mice upon intracerebral inoculation of the virus. This result suggests that besides arginine at position 333, some other positions of G protein might also be involved in determining the virulence of rabies virus.
虽然狂犬病病毒的RC-HL毒株对成年小鼠无毒力，但其G蛋白第333位的氨基酸是精氨酸，据认为该氨基酸对于病毒脑内接种后在成年小鼠中的毒力是必需的。这一结果表明，除了第333位的精氨酸外，G蛋白的其他一些位置可能也参与决定狂犬病病毒的毒力。
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