Dujmović F
Institut za patolosku fiziologiju, Medicinski fakultet, Novi Sad.
Med Pregl. 1993;46(7-8):264-7.
After splenectomy for traumatic spleen rupture posttraumatic asplenia occurs. In such a state different pathophysiological changes occur in the peripheral blood and in the immunologic response as well as local changes in the form of splenosis, that is, changes due to trauma-induced autotransplantate of the spleen tissue particle. The study discusses as yet obscure pathogenesis, consequences and significance of these changes, including an increased incidence of sepsis (postsplenectomy sepsis, the so-called OPSI syndrome). In a series of eight patients with posttraumatic asplenia, in seven cases splenosis was detected by means of scintigraphy with labeled erythrocytes. Although splenosis is rarely found in general population, and is usually asymptomatic, diagnostic procedures show that it can mimic other pathological processes causing differential diagnostic difficulties. Because of this the authors are of the opinion that the detection of splenosis necessitates a scintigraphic examination of splenectomized patients; if it is confirmed is should be recorded in medical documentation.
外伤性脾破裂行脾切除术后会发生创伤后无脾状态。在这种状态下，外周血和免疫反应会出现不同的病理生理变化，同时还会出现脾组织异位等局部变化，即由创伤引起的脾组织颗粒自体移植所致的变化。该研究探讨了这些变化尚未明确的发病机制、后果及意义，包括败血症（脾切除术后败血症，即所谓的OPSI综合征）发病率增加。在一组8例创伤后无脾患者中，7例通过标记红细胞闪烁扫描检测到脾组织异位。尽管脾组织异位在普通人群中很少见，且通常无症状，但诊断程序表明它可能会模仿其他病理过程，导致鉴别诊断困难。因此，作者认为，对于脾切除患者有必要进行闪烁扫描检查以检测脾组织异位；如果得到证实，应记录在医疗文件中。
