Bovicelli L
Policlinico S. Orsola-Malpighi, Università degli Studi di Bologna.
Minerva Endocrinol. 1994 Jun;19(2):85-9.
In the diabetic pregnant woman, together with monitoring of carbohydrate metabolism, it is of vital importance the fetal monitoring which includes: the dating of onset of pregnancy, the diagnosis of malformation, the evaluation of fetal health. The dating of onset of pregnancy can be calculated fairly precisely measuring echographically the vertex-sacrum length and the biparietal diameter carried out respectively in the first 12 and 20 weeks of amenorrhoea. The diagnosis of malformation can be effected by traditional echography or by transvaginal echography, a new method which allows an early diagnosis of serious malformation in high risk patients. Fetal health can be evaluated by the oxytocin test, non-stress test, biophysical profile and Doppler velocimeter. All these techniques have advantages and disadvantages, of which the most misleading is the high frequency of false positives (low specificity). In the diabetic pregnant woman, to foresee fetal maturity, it is advisable to utilize a more elevated lecithin-sphingomyelin ratio (over 3-3.5) than to non-diabetic pregnant women because of less precision of this test when diabetes is present. The dosage of phosphatidyl-glycerol in the amniotic fluid may also be useful. Echography evaluation of the fetal weight is reliable above all for low or normal weight while it is less so for fetuses of high weight. The ratio between cranium and abdomen circumferences is still considered one of the best indexes to foresee macrosomia.
对于糖尿病孕妇,除了监测碳水化合物代谢外,胎儿监测至关重要,包括:确定妊娠开始时间、诊断畸形、评估胎儿健康状况。妊娠开始时间可通过超声测量顶骶长度和双顶径来较为精确地计算,分别在停经后的第12周和第20周进行。畸形诊断可通过传统超声或经阴道超声进行,经阴道超声是一种新方法,可对高危患者的严重畸形进行早期诊断。胎儿健康状况可通过催产素试验、无应激试验、生物物理评分和多普勒测速仪进行评估。所有这些技术都有优缺点,其中最具误导性的是假阳性频率高(特异性低)。对于糖尿病孕妇,由于糖尿病存在时该检测的准确性较低,因此建议使用比非糖尿病孕妇更高的卵磷脂 - 鞘磷脂比值(超过3 - 3.5)来预测胎儿成熟度。羊水磷脂酰甘油的测定也可能有用。超声评估胎儿体重对于低体重或正常体重胎儿最为可靠,而对于高体重胎儿则可靠性较低。头围与腹围之比仍被认为是预测巨大儿的最佳指标之一。