Dehner L P, Gersell D J
Washington University School of Medicine, St. Louis, Missouri.
Mo Med. 1994 Oct;91(10):630-5.
Congenital syphilis had almost become a forgotten disease with the advent of maternal prenatal serology and penicillin therapy for infected mothers. From the 1950s into the mid-1980s, cases of congenital syphilis steadily declined to only 688 cases in the United States in 1988; however, the number of cases increased to 2,841 by 1990. The heralding event occurred between 1981 and 1989 with a 34% increase nationally in the incidence of primary and secondary syphilis. A peak in the number of cases of congenital syphilis was attained in 1992 in the country at large, but in 1993 in the State of Missouri, there were almost three times as many cases as were reported in 1992. Physicians, particularly those who practice in the metropolitan areas of the state, should be alert to the clinical profile of prospective mothers who may have primary or secondary syphilis.
随着针对感染母亲的孕产妇产前血清学检查和青霉素疗法的出现，先天性梅毒几乎已成为一种被遗忘的疾病。从20世纪50年代到80年代中期，先天性梅毒病例稳步下降，到1988年美国仅有688例；然而，到1990年病例数增至2841例。标志性事件发生在1981年至1989年期间，全国一期和二期梅毒发病率上升了34%。1992年全国先天性梅毒病例数达到峰值，但在密苏里州，1993年的病例数几乎是1992年报告病例数的三倍。医生，尤其是在该州大都市地区执业的医生，应警惕可能患有一期或二期梅毒的准母亲的临床特征。
