Woo K T, Lau Y K, Wong K S, Lee G S, Chin Y M, Chiang G S, Lim C H
Department of Renal Medicine, Singapore General Hospital.
Nephron. 1994;67(4):408-13. doi: 10.1159/000188013.
Proteinuria in 13 patients with IgA nephritis with nephrotic syndrome (IgANS) was analysed by isoelectric focusing (IEF) and compared with 12 patients with minimal change nephrotic syndrome (MCNS) (n = 8) or focal global sclerosis nephrotic syndrome (FGS) (n = 4) to determine the pattern of proteinuria on IEF and to assess the value of IEF and protein selectivity index (SI) as predictors of response to therapy with predisolone or cyclophosphamide. Steroid/cyclophosphamide responsive patients with IgANS had SC:UA (cationic serum albumin with anionic urine albumin) or SA:UC (anionic serum albumin with cationic urine albumin) IEF patterns and steroid/cyclophosphamide unresponsive patients with IgANS had an SC:UC (cationic serum albumin with cationic urine albumin) IEF pattern. The majority of patients with MCNS or FGS who had an SA:UC IEF pattern were steroid responsive. SI was a better predictor of steroid/cyclophosphamide responsiveness in patients with IgANS (r = 0.78, p < 0.002 compared to IEF, r = 0.64, p < 0.02).
采用等电聚焦（IEF）分析法对13例IgA肾病合并肾病综合征（IgANS）患者的蛋白尿进行分析，并与12例微小病变肾病综合征（MCNS）患者（n = 8）或局灶性节段性肾小球硬化肾病综合征（FGS）患者（n = 4）进行比较，以确定IEF上的蛋白尿模式，并评估IEF和蛋白选择性指数（SI）作为预测泼尼松龙或环磷酰胺治疗反应的价值。IgANS中对类固醇/环磷酰胺治疗有反应的患者具有SC:UA（阳离子血清白蛋白与阴离子尿白蛋白）或SA:UC（阴离子血清白蛋白与阳离子尿白蛋白）IEF模式，而IgANS中对类固醇/环磷酰胺治疗无反应的患者具有SC:UC（阳离子血清白蛋白与阳离子尿白蛋白）IEF模式。大多数具有SA:UC IEF模式的MCNS或FGS患者对类固醇治疗有反应。在IgANS患者中，SI是类固醇/环磷酰胺反应性的更好预测指标（r = 0.78，与IEF相比，p < 0.002，IEF的r = 0.64，p < 0.02）。
