Kasamo K, Tada K, Ueda N, Kojima T, Kogure M, Ishikawa K
Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo, Japan.
Neuropharmacology. 1994 Jul;33(7):905-14. doi: 10.1016/0028-3908(94)90189-9.
We examined the effect of 5-hydroxytryptamine (5-HT)1A agonists on walking related, atropine-resistant, rhythmical slow activity (wr-RSA) of the hippocampus in rats. Selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), flesinoxan, buspirone and ipsapirone significantly decreased the power value of 7-9 Hz band activity and the median frequency of wr-RSA. The order of potency was 8-OH-DPAT > flesinoxan = buspirone in power reduction. The 5-HT1A antagonists, (-)pindolol, (-)propranolol and spiperone, inhibited the effect of 8-OH-DPAT on wr-RSA. Pretreatment with parachlorophenylalanine did not abolish the effect of 8-OH-DPAT. These results indicate that 5-HT1A agonists reduce both power and median frequency values of wr-RSA through activation of post-synaptic 5-HT1A receptors in the forebrain in unanesthetized rats, in vivo.
我们研究了5-羟色胺（5-HT）1A激动剂对大鼠海马中与行走相关的、阿托品抵抗性的节律性慢活动（wr-RSA）的影响。选择性5-HT1A激动剂，8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）、氟司必林、丁螺环酮和伊沙匹隆显著降低了7-9Hz频段活动的功率值以及wr-RSA的中位频率。在降低功率方面，效力顺序为8-OH-DPAT>氟司必林=丁螺环酮。5-HT1A拮抗剂，（-）吲哚洛尔、（-）普萘洛尔和螺哌隆，抑制了8-OH-DPAT对wr-RSA的作用。对氯苯丙氨酸预处理并未消除8-OH-DPAT的作用。这些结果表明，在未麻醉的大鼠体内，5-HT1A激动剂通过激活前脑的突触后5-HT1A受体来降低wr-RSA的功率值和中位频率值。
