Eggert F, Uharek L, Müller-Ruchholtz W, Ferstl R
Department of Psychology, University of Kiel, FRG.
Neuropsychobiology. 1994;30(1):42-5. doi: 10.1159/000119134.
The change in genetically determined urine odors which appears after experimental bone marrow transplantations in mice was examined in order to test whether the HMC is the only group of genes that influences the chemosensory identity via the hematopoietic system. 5 female rats were trained in a computer-controlled olfactometer to discriminate urine odors of two MHC congenic or background congenic inbred strains of mice. Transfer-of-training tests with urine samples of irradiated mice which were restored with bone marrow either from an MHC congenic or a background congenic inbred strain reveal a change of urinary chemosignals after both types of experimental bone marrow transplantation. Thus, both MHC-associated as well as MHC-independent urinary chemosignals are expressed via the hematopoietic system.
为了测试主要组织相容性复合体（HMC）是否是唯一通过造血系统影响化学感应特性的基因群，研究人员检测了小鼠实验性骨髓移植后基因决定的尿液气味变化。5只雌性大鼠在计算机控制的嗅觉计中接受训练，以区分两种主要组织相容性复合体（MHC）同基因或背景同基因近交系小鼠的尿液气味。对接受了来自MHC同基因或背景同基因近交系骨髓移植的受辐照小鼠的尿液样本进行训练转移测试，结果显示两种类型的实验性骨髓移植后尿液化学信号均发生了变化。因此，与MHC相关以及与MHC无关的尿液化学信号均通过造血系统表达。
