Fernandez A, de Ceballos M L, Jenner P, Marsden C D
Department of Neuropharmacology, Cajal Institute, CSIC, Madrid, Spain.
Neuroscience. 1994 Jul;61(1):73-9. doi: 10.1016/0306-4522(94)90061-2.
The specific binding of [3H]neurotensin, [3H]substance P, [3H]D-Ala2-D-Leu5-enkephalin (delta receptors) and [3H]-Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol (mu receptors) were studied in membrane preparations of caudate nucleus, putamen, globus pallidus and substantia nigra from patients with Parkinson's disease and from age-matched controls. The density of neurotensin receptors was decreased in globus pallidus (lateral and medial segments) in parkinsonian brain. Substance P receptors were reduced in the putamen (anterior and posterior) and in lateral globus pallidus in Parkinson's disease. There was a reduction in the density of opioid receptors in posterior putamen and in mu receptors in caudate nucleus and putamen (anterior and posterior). No differences in neuropeptide receptor binding were observed in substantia nigra from parkinsonian brains compared with control subjects. The reductions in neuropeptide receptor density were less marked than the decrease in caudate and putamen content of dopamine and its metabolites. This suggests that neuropeptide receptors are only partially localized to striatal dopamine terminals.
研究了帕金森病患者及年龄匹配的对照者尾状核、壳核、苍白球和黑质膜制剂中[3H]神经降压素、[3H]P物质、[3H]D-丙氨酸2-D-亮氨酸5-脑啡肽（δ受体）和[3H]-酪氨酸-D-丙氨酸-甘氨酸-（N-甲基）苯丙氨酸-甘氨酸-醇（μ受体）的特异性结合。帕金森病脑苍白球（外侧和内侧段）中神经降压素受体密度降低。帕金森病患者壳核（前部和后部）及外侧苍白球中P物质受体减少。尾状核后部及壳核（前部和后部）中阿片受体密度及μ受体密度降低。与对照者相比，帕金森病脑黑质中神经肽受体结合无差异。神经肽受体密度的降低不如尾状核和壳核中多巴胺及其代谢产物含量的降低明显。这表明神经肽受体仅部分定位于纹状体多巴胺终末。
