Roberts R C, Part N J, Pokorny R, Muir C, Leslie G C, Emre M
Department of Medicine, Dundee University, Scotland, United Kingdom.
Neurology. 1994 Nov;44(11 Suppl 9):S29-31.
The relationship among tizanidine dose, plasma concentration, and antispastic action is linear in nature. Response to a given dose of this agent varies among patients, and determining the appropriate clinical dose requires individual titration.