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Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus.

作者信息

Yang H, Taché Y

机构信息

CURE/Gastroenteric Biology Center, VA Wadsworth Medical Center, Los Angeles, CA 90073.

出版信息

Neurosci Lett. 1994 Jun 6;174(1):43-6. doi: 10.1016/0304-3940(94)90114-7.

DOI:10.1016/0304-3940(94)90114-7
PMID:7970152
Abstract

Prepro-TRH-(160-169) (Ps4), one of the predicted connecting peptides of pro-TRH, potentiates TRH-induced TSH release in vivo and in vitro. The influence of Ps4 on TRH in medullary nuclei-induced vagal stimulation of gastric acid secretion was studied in urethane-anesthetized rats with gastric cannula. Ps4 injected into the dorsal motor nucleus of the vagus (DMN) (200 ng) did not influence basal gastric secretion. Ps4 (100, 150 and 200 ng) co-injected with TRH (50 ng) into the DMN potentiated the acid response to TRH by 14%, 76% and 182% respectively while prepro-TRH-(178-199) (Ps5, 438 ng) had no effect. Ps4 (200 ng) co-injected with TRH into the nucleus ambiguus did not modify TRH (50 ng)-induced acid secretion. These results indicate that Ps4 potentiates TRH in the DMN-evoked gastric acid secretion through an action that is peptide and site specific.

摘要

相似文献

1
Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus.
Neurosci Lett. 1994 Jun 6;174(1):43-6. doi: 10.1016/0304-3940(94)90114-7.
2
PYY in brain stem nuclei induces vagal stimulation of gastric acid secretion in rats.
Am J Physiol. 1995 Jun;268(6 Pt 1):G943-8. doi: 10.1152/ajpgi.1995.268.6.G943.
3
Medullary sites of action of the TRH analogue, RX 77368, for stimulation of gastric acid secretion in the rat.促甲状腺激素释放激素类似物RX 77368刺激大鼠胃酸分泌的延髓作用部位。
Gastroenterology. 1988 Dec;95(6):1470-6. doi: 10.1016/s0016-5085(88)80065-9.
4
TRH analogue, RX 77368, injected into dorsal vagal complex stimulates gastric secretion in rats.将促甲状腺激素释放激素类似物RX 77368注入大鼠迷走神经背侧复合体可刺激其胃液分泌。
Am J Physiol. 1988 May;254(5 Pt 1):G639-43. doi: 10.1152/ajpgi.1988.254.5.G639.
5
Enhancement of gastric acid output and mucosal blood flow by tripeptide thyrotropin releasing hormone microinjected into the dorsal motor nucleus of the vagus in rats.向大鼠迷走神经背运动核微量注射三肽促甲状腺激素释放激素可增强胃酸分泌和黏膜血流。
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6
Omega-conotoxin- and nifedipine-insensitive voltage-operated calcium channels mediate K(+)-induced release of pro-thyrotropin-releasing hormone-connecting peptides Ps4 and Ps5 from perifused rat hypothalamic slices.ω-芋螺毒素和硝苯地平不敏感的电压门控钙通道介导钾离子诱导的促甲状腺激素释放激素连接肽Ps4和Ps5从灌流大鼠下丘脑切片中的释放。
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7
Processing of thyrotropin-releasing hormone prohormone (pro-TRH) generates a biologically active peptide, prepro-TRH-(160-169), which regulates TRH-induced thyrotropin secretion.促甲状腺激素释放激素原（pro-TRH）的加工产生一种生物活性肽，即前促甲状腺激素释放激素-（160-169），它调节促甲状腺激素释放激素诱导的促甲状腺激素分泌。
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4439-43. doi: 10.1073/pnas.87.12.4439.
8
Is Ps4 (prepro-TRH [160-169]) more than an enhancer for thyrotropin-releasing hormone?促甲状腺激素释放激素前体（160 - 169）是否不仅仅是促甲状腺激素释放激素的增强剂？
Thyroid. 1998 Oct;8(10):963-8. doi: 10.1089/thy.1998.8.963.
9
Gastric effects of thyrotropin-releasing hormone microinjected into the dorsal vagal nucleus in cats.
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Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathways.中缝苍白核神经元的激活通过延髓促甲状腺激素释放激素（TRH）-迷走神经通路增加胰岛素分泌。
Pancreas. 2002 Oct;25(3):301-7. doi: 10.1097/00006676-200210000-00014.

引用本文的文献

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Inhibition of prolactin secretion from the male rat anterior pituitary by cryptic sequences of prothyrotropin releasing hormone, ProTRH178-199 and ProTRH186-199.
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