Nagao T, Avoli M, Gloor P
Montreal Neurological Institute, Quebec, Canada.
Neurosci Lett. 1994 Jun 20;174(2):160-4. doi: 10.1016/0304-3940(94)90011-6.
Systemic administration of pilocarpine to adult rats induces an acute status epilepticus followed by spontaneous recurrent seizures after a 1-2-week silent period. We recorded field potentials in hippocampal slices obtained from rats with spontaneous recurrent seizures after pilocarpine-induced status. The frequency of the interictal discharges induced in these slices by 4-aminopyridine (4AP) was reduced and their duration was increased. Cutting the Schaffer collaterals caused interictal discharges in CA1 to disappear in normal rats and in rats 3 weeks after pilocarpine-induced status. However, 12 weeks after pilocarpine, these discharges remained in CA1 after such a cut but occurred at a lower frequency. These findings show that in rat hippocampi with a lesion similar to that of human Ammon's horn sclerosis some electrophysiological features of 4AP-induced interictal discharges are altered in comparison to those induced in normal hippocampi.
对成年大鼠进行毛果芸香碱的全身给药会诱发急性癫痫持续状态，随后在1至2周的静止期后出现自发性复发性癫痫发作。我们记录了从毛果芸香碱诱发癫痫持续状态后出现自发性复发性癫痫发作的大鼠获取的海马切片中的场电位。4-氨基吡啶（4AP）在这些切片中诱发的发作间期放电频率降低，其持续时间增加。切断海马旁回在正常大鼠和毛果芸香碱诱发癫痫持续状态3周后的大鼠中会使CA1区的发作间期放电消失。然而，在毛果芸香碱给药12周后，切断海马旁回后这些放电仍存在于CA1区，但频率较低。这些发现表明，在与人类海马硬化病变相似的大鼠海马中，与正常海马中诱发的4AP发作间期放电相比，其一些电生理特征发生了改变。
