胶质纤维酸性蛋白基因在人类胚胎中的发育表达。

Developmental expression of glial fibrillary acidic protein gene in human embryos.

作者信息

Voronina A S, Preobrazhensky A A

机构信息

A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow.

出版信息

Neurosci Lett. 1994 Jun 20;174(2):198-200. doi: 10.1016/0304-3940(94)90020-5.

DOI:10.1016/0304-3940(94)90020-5

PMID:7970178

Abstract

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein of astrocytes. We have shown by Northern blot analysis that GFAP mRNA first appears in the spinal cord at the age of 8 weeks and in the brain at the age of 9 weeks of embryogenesis, and its relative contents increases at later stages. A plasmid selected from a cDNA expression library with an insert encoding for almost full length of human GFAP was used in this study.

摘要

胶质纤维酸性蛋白（GFAP）是星形胶质细胞的一种中间丝蛋白。我们通过Northern印迹分析表明，GFAP mRNA在胚胎发育8周时首次出现在脊髓中，9周时出现在大脑中，其相对含量在后期增加。本研究使用了从cDNA表达文库中筛选出的一个质粒，其插入片段编码几乎全长的人GFAP。