不同麻醉剂对大鼠脑内Fos蛋白表达影响的比较。
The comparison of effects of various anesthetics on expression of Fos protein in the rat brain.
作者信息
Takayama K, Suzuki T, Miura M
机构信息
Department of Physiology 1st Division, Gunma University School of Medicine, Maebashi-shi, Japan.
出版信息
Neurosci Lett. 1994 Jul 18;176(1):59-62. doi: 10.1016/0304-3940(94)90871-0.
The purpose of this study was to compare effects of various anesthetic drugs on expression of Fos protein in the supraspinal neurons of rats. Optimum anesthesia was maintained under monitoring of EEG. Degree of Fos expression was evaluated by counts of Fos-immunoreactive (ir) neurons. Urethane induced the largest amount of Fos-ir neurons (n = 8439), while fentanyl/midazolam the smallest (n = 112). alpha-Chloralose, halothane, pentobarbital sodium and urethane/alpha-chloralose induced amounts in between. The results indicate that fentanyl/midazolam is the most recommendable anesthetic drug in the Fos expression study.
本研究的目的是比较各种麻醉药物对大鼠脊髓上神经元中Fos蛋白表达的影响。在脑电图监测下维持最佳麻醉状态。通过对Fos免疫反应性（ir）神经元的计数来评估Fos表达程度。氨基甲酸乙酯诱导的Fos-ir神经元数量最多（n = 8439），而芬太尼/咪达唑仑诱导的数量最少（n = 112）。α-氯醛糖、氟烷、戊巴比妥钠和氨基甲酸乙酯/α-氯醛糖诱导的数量介于两者之间。结果表明，在Fos表达研究中，芬太尼/咪达唑仑是最值得推荐的麻醉药物。
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