Mahmood S, Gupta N K, Gunning M, Bomanji J B, Jarritt P H, Ell P J
Institute of Nuclear Medicine, University College London Medical School, UK.
Nucl Med Commun. 1994 Aug;15(8):586-92. doi: 10.1097/00006231-199408000-00003.
201Tl myocardial perfusion single photon emission tomography (SPET) with pharmacological coronary vasodilatation using adenosine is now often used in the investigation of a patient with ischaemic heart disease (IHD). In this study, we present data from two groups of patients. Group A (n = 40) experienced 201Tl SPET with adenosine only as the pharmacological stress test, using an infusion rate of 140 micrograms kg-1 min-1. Group B patients (n = 50) had the same test combined with low-level dynamic exercise. The side effects were noted for both groups and 201Tl SPET studies were acquired for stress and redistribution images. There was a lesser degree of non-cardiac side effects in patients of group B. There was a significant difference in the haemodynamic parameters between the two groups. There was no significant difference in overall sensitivity (87% versus 90%) and specificity (84% versus 88%) in the detection of IHD between the two groups. In conclusion, addition of low-level dynamic exercise with adenosine is to be preferred to adenosine infusion alone, as this protocol is better tolerated and may enhance the detection of right coronary artery disease (sensitivity = 82% versus 90%, n.s.).
使用腺苷进行药物性冠状动脉血管扩张的201铊心肌灌注单光子发射断层扫描（SPET）目前常用于缺血性心脏病（IHD）患者的检查。在本研究中，我们展示了两组患者的数据。A组（n = 40）仅使用腺苷作为药物应激试验进行201铊SPET检查，输注速率为140微克/千克/分钟。B组患者（n = 50）进行相同的检查并结合低水平动态运动。记录两组的副作用，并获取201铊SPET研究的应激和再分布图像。B组患者的非心脏副作用程度较轻。两组之间的血流动力学参数存在显著差异。两组在检测IHD方面的总体敏感性（87%对90%）和特异性（84%对88%）没有显著差异。总之，腺苷联合低水平动态运动比单独使用腺苷输注更可取，因为该方案耐受性更好，可能会提高右冠状动脉疾病的检测率（敏感性 = 82%对90%，无统计学意义）。
