Ettl A, Fischer-Klein C, Chemelli A, Daxer A, Felber S
Department of Ophthalmology, University of Innsbruck, Austria.
Ophthalmologica. 1994;208(4):195-7. doi: 10.1159/000310486.
We performed proton magnetic resonance imaging of the vitreous body in a 37-year-old mother and her 14-year-old son who suffered from autosomal dominant vitreoretinal dystrophy. Both showed the characteristic signs of the disease including premature liquefaction of the vitreous. Magnetic resonance imaging at 1.5 T using a standard head coil yielded a shortened mean (+/- SD) transverse proton relaxation time (T2) of the vitreous in our patients (T2 = 311 +/- 22 ms) in comparison with 8 eyes of normal volunteers (T2 = 546 +/- 157 ms). The longitudinal proton relaxation time (T1) showed a tendency towards lower values in the patients (T1 = 2,928 +/- 207 ms) but was not significantly decreased when compared with normal volunteers (T1 = 3,257 +/- 307 ms). The decrease in the T2 times in our patients is in accordance with previous in vitro studies of artificial vitreous liquefaction in bovine eyes and provides information on the mechanism of vitreous liquefaction in vitreoretinal dystrophy.
我们对一名37岁的母亲及其14岁患有常染色体显性遗传性玻璃体视网膜营养不良的儿子的玻璃体进行了质子磁共振成像检查。两人均显示出该疾病的特征性体征，包括玻璃体过早液化。使用标准头部线圈在1.5T磁场下进行磁共振成像，结果显示，与8名正常志愿者的眼睛（T2 = 546 +/- 157毫秒）相比，我们的患者玻璃体的平均横向质子弛豫时间（T2）缩短（T2 = 311 +/- 22毫秒）。纵向质子弛豫时间（T1）在患者中显示出较低值的趋势（T1 = 2928 +/- 207毫秒），但与正常志愿者相比没有显著降低（T1 = 3257 +/- 307毫秒）。我们患者中T2时间的缩短与之前对牛眼人工玻璃体液化的体外研究结果一致，并为玻璃体视网膜营养不良中玻璃体液化的机制提供了信息。
