Gill P, VanHook J, FitzSimmons J, Pascoe-Mason J, Fantel A
Department of Obstetrics and Gynecology, University of Washington, Seattle 98195.
Pediatr Pathol. 1994 Jul-Aug;14(4):609-15. doi: 10.3109/15513819409023335.
To investigate if fetuses with cystic hygroma colli have ear article dysmorphism, we studied 16 fetuses with cystic hygroma colli, all of which had 45,X karyotype, and 107 normal fetuses. All the specimens were second-trimester formalin-preserved human fetuses. The ear lengths and widths were measured and ear indices (length/width) calculated. There were no significant differences in the ear measurements of age-matched normal male and female fetuses (P > .05). Ear growth was less linear in the cystic hygroma colli group than in the normal fetuses; Pearson's coefficient .45 vs. .87 for ear length, and r = .77 vs. .88 for ear width. The mean (+/- SD) ear index of the normal fetuses was 1.56 +/- 0.22 compared to 2.10 +/- 0.36 of the cystic hygroma colli fetuses, P < .001. The ear dysmorphism (> 2 SD of gestational age norm) was observed in 6.3% (1/16) of the ear widths, 56.3% (9/16) of the ear lengths, and 62.5% (10/16) of the ear indices. We conclude that cystic hygroma colli fetuses with 45,X have unique ear auricle morphology.
为了研究患有颈部水囊瘤的胎儿是否存在耳部形态异常，我们研究了16例患有颈部水囊瘤的胎儿（所有胎儿核型均为45,X）以及107例正常胎儿。所有标本均为孕中期用福尔马林保存的人类胎儿。测量了耳部的长度和宽度，并计算了耳指数（长度/宽度）。年龄匹配的正常男性和女性胎儿的耳部测量值无显著差异（P>0.05）。颈部水囊瘤组的耳部生长线性程度低于正常胎儿；耳部长度的皮尔逊系数分别为0.45和0.87，耳部宽度的r值分别为0.77和0.88。正常胎儿的平均（±标准差）耳指数为1.56±0.22，而颈部水囊瘤胎儿的耳指数为2.10±0.36，P<0.001。在耳部宽度中，6.3%（1/16）、耳部长度中56.3%（9/16）以及耳指数中62.5%（10/16）观察到耳部形态异常（>胎龄正常范围的2个标准差）。我们得出结论，核型为45,X的颈部水囊瘤胎儿具有独特的耳廓形态。
