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无论是否受到选择性D2多巴胺激动剂SND 919的刺激,(-)司来吉兰均无法改变雄性大鼠的交配行为。

Inability of (-)deprenyl to modify copulatory performance in the male rat, whether or not stimulated by the selective D2 dopamine agonist SND 919.

作者信息

Ferrari F, Giuliani D

机构信息

Department of Biomedical Sciences, University of Modena, Italy.

出版信息

Pharmacol Res. 1994 May-Jun;29(4):373-82. doi: 10.1016/1043-6618(94)80059-6.

Abstract

Intraperitoneal injection of the selective D2 dopamine agonist SND 919 (0.1 and 1 mg kg-1) significantly accelerated the copulatory behaviour of sexually-active rats, diminishing the number of mounts, intromissions and latency to ejaculation. Subchronic (-)deprenyl did not produce any significant effect on the copulatory behaviour of sexually-active and -inactive male rats or modify the sexual stimulation exerted on the same sexually-active rats by SND 919, when acutely injected at 1 mg kg-1.

摘要

腹腔注射选择性D2多巴胺激动剂SND 919(0.1和1毫克/千克)可显著加速性活跃大鼠的交配行为,减少爬跨、插入次数及射精潜伏期。亚慢性给予(-)司来吉兰对性活跃和性不活跃雄性大鼠的交配行为均未产生任何显著影响,也未改变在急性注射1毫克/千克时SND 919对相同性活跃大鼠施加的性刺激。

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