Gotwals P J, Fessler L I, Wehrli M, Hynes R O
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11447-51. doi: 10.1073/pnas.91.24.11447.
We have expressed Drosophila position-specific (PS) integrins on the surfaces of Schneider S2 cells and tested for adhesion and spreading on various matrix molecules. We report that PS1 integrin is a laminin receptor and that PS1 and PS2 integrins promote cell spreading on two different Drosophila extracellular matrix molecules, laminin and tiggrin, respectively. The differing ligand specificities of these two integrins, combined with data on the in vivo expression patterns of the integrins and their ligands, lead to a model for the structure of integrin-dependent attachments in the pupal wings and embryonic muscles of Drosophila.
我们已在施耐德S2细胞表面表达了果蝇位置特异性（PS）整合素，并测试了其在各种基质分子上的黏附与铺展情况。我们报告称，PS1整合素是一种层粘连蛋白受体，且PS1和PS2整合素分别促进细胞在两种不同的果蝇细胞外基质分子——层粘连蛋白和tiggrin上的铺展。这两种整合素不同的配体特异性，再结合整合素及其配体的体内表达模式数据，得出了一个关于果蝇蛹翅和胚胎肌肉中整合素依赖性附着结构的模型。
