神经母细胞瘤大规模筛查的效果及该肿瘤的推测自然史。

Takeda T, Shimada M, Iizuka S, Takasugi N

Clinical Research Institute, Sapporo National Hospital.

Prog Clin Biol Res. 1994;385:383-8.

By March 1992, 166,959 infants were screened in Sapporo City, and 35 patients were found to have this tumor. Incidence of this tumor in our screening was one among 5,059 babies examined. 2) Eleven infants among the group with negative screening at 6 months developed neuroblastoma later. The patients developed tumors one to several years after mass screening, and 2/3 of these cases showed high urinary HVA compared to VMA. 3) We postulate that some of the adrenal steroids, possibly cortisol, may play a role for the malignant progression of this tumor.

到1992年3月，札幌市对166,959名婴儿进行了筛查，发现35例患有这种肿瘤。在我们的筛查中，这种肿瘤的发病率为每5,059名受检婴儿中有1例。2) 6个月时筛查结果为阴性的婴儿组中有11名后来患上了神经母细胞瘤。这些患者在大规模筛查后1至数年患上肿瘤，其中2/3的病例尿高香草酸（HVA）与香草扁桃酸（VMA）相比含量较高。3) 我们推测某些肾上腺类固醇，可能是皮质醇，可能在这种肿瘤的恶性进展中起作用。

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核心技术专利：CN118964589B侵权必究

Takeda T, Shimada M, Iizuka S, Takasugi N

Clinical Research Institute, Sapporo National Hospital.

Prog Clin Biol Res. 1994;385:383-8.

By March 1992, 166,959 infants were screened in Sapporo City, and 35 patients were found to have this tumor. Incidence of this tumor in our screening was one among 5,059 babies examined. 2) Eleven infants among the group with negative screening at 6 months developed neuroblastoma later. The patients developed tumors one to several years after mass screening, and 2/3 of these cases showed high urinary HVA compared to VMA. 3) We postulate that some of the adrenal steroids, possibly cortisol, may play a role for the malignant progression of this tumor.

到1992年3月，札幌市对166,959名婴儿进行了筛查，发现35例患有这种肿瘤。在我们的筛查中，这种肿瘤的发病率为每5,059名受检婴儿中有1例。2) 6个月时筛查结果为阴性的婴儿组中有11名后来患上了神经母细胞瘤。这些患者在大规模筛查后1至数年患上肿瘤，其中2/3的病例尿高香草酸（HVA）与香草扁桃酸（VMA）相比含量较高。3) 我们推测某些肾上腺类固醇，可能是皮质醇，可能在这种肿瘤的恶性进展中起作用。