剂量和给药间隔对多巴胺激动剂喹吡罗运动致敏的影响。
Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole.
作者信息
Szechtman H, Dai H, Mustafa S, Einat H, Sullivan R M
机构信息
Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
出版信息
Pharmacol Biochem Behav. 1994 Aug;48(4):921-8. doi: 10.1016/0091-3057(94)90201-1.
To assess whether the interval between injections affects the course of locomotor sensitization to quinpirole, groups of rats were injected every 2, 4, or 8 days with quinpirole (0, 0.025, 0.25, 0.5, and 2.5 mg/kg; n = 222) and their locomotor activity monitored after each injection for a total of 10 tests. Results indicate that the number of drug injections, rather than the interval between them, predominantly controls the development of locomotor sensitization to quinpirole. It is suggested that this may reflect a rapid induction but slow decay time for a response-enhancing factor stimulated by each injection of quinpirole, and that the effects of this putative factor are cumulative but saturable.
为了评估注射间隔是否会影响对喹吡罗的运动敏化过程，将大鼠分组，每2天、4天或8天注射一次喹吡罗（剂量为0、0.025、0.25、0.5和2.5mg/kg；n = 222），每次注射后监测其运动活动，共进行10次测试。结果表明，药物注射的次数而非注射间隔，在很大程度上控制了对喹吡罗的运动敏化的发展。这表明，这可能反映了每次注射喹吡罗所刺激的反应增强因子的快速诱导但缓慢衰减时间，并且这种假定因子的作用是累积性的但会饱和。
Zotero 插件