Lipnicka U, Regiec A, Machon Z
Organic Chemistry Department, Faculty of Pharmacy, Medical Academy, Wroclaw, Poland.
Pharmazie. 1994 Sep;49(9):642-6.
The synthesis of new 5-amino-3-methylisothiazolo[5,4-d]pyrimidines series is reported. The cytotoxic activity of these compounds has been determined on the two tumor cell lines (P-388 and KB). Two representative compounds 7 and 8 displayed a significant cytotoxic action. The results point a possible involvement of structural features in the inhibition effect against tumors.
