Chang F Y, Lee S D, Yeh G H, Wang P S
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Pharmacology. 1994 Sep;49(3):151-8. doi: 10.1159/000139229.
Rat gastrointestinal (GI) transit parameters measured with charcoal and radiochromium were compared. Animals were fed with a calorie-free liquid test meal which contained 10% charcoal and radiochromium (0.5 microCi ml-1) via a transiently placed orogastric catheter. The rats were sacrificed at 1, 5, 15, 30, 60 and 120 min, respectively, since feeding. Various motor parameters were measured. Charcoal transit ratio, gastric emptying and geometric center were time dependent. Charcoal transit ratio occasionally showed a positive correlation with gastric emptying in the very late experimental periods. Concerning the correlation of charcoal transit ratio and geometric center, negative and positive correlations were seen in the very early and late periods, respectively. We conclude that the rat charcoal transit ratio has limited value to replace the GI transit parameters determined by feeding radiochromium.
比较了用木炭和放射性铬测量的大鼠胃肠（GI）转运参数。通过临时放置的口胃导管给动物喂食不含热量的液体测试餐，该餐含有10%的木炭和放射性铬（0.5微居里/毫升）。自喂食后，分别在1、5、15、30、60和120分钟处死大鼠。测量了各种运动参数。木炭转运率、胃排空和几何中心与时间有关。在实验后期，木炭转运率偶尔与胃排空呈正相关。关于木炭转运率与几何中心的相关性，在早期和后期分别观察到负相关和正相关。我们得出结论，大鼠木炭转运率在替代通过喂食放射性铬确定的胃肠转运参数方面价值有限。
