Martin G R
Analytical Pharmacology Group, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Pharmacol Ther. 1994;62(3):283-324. doi: 10.1016/0163-7258(94)90048-5.
The complex actions of 5-hydroxytryptamine (5-HT) on blood vessels result from interactions with a multiplicity of specific 5-HT receptors. Dramatic advances recently have been made in defining the receptor subtypes involved in terms of their pharmacology and biochemistry, as well as their molecular biology, provoking an evolution of the criteria used for classifying and naming them. This article reviews the distribution and function of different 5-HT receptor types present on vascular smooth muscle, endothelium and perivascular neurones, and considers ways in which they can be positively defined and differentiated using traditional pharmacological approaches. The characteristics of each receptor type are also considered in terms of current biochemical and molecular perspectives on 5-HT receptor classification.
5-羟色胺（5-HT）对血管的复杂作用源于其与多种特异性5-HT受体的相互作用。最近在确定参与其中的受体亚型的药理学、生物化学以及分子生物学方面取得了显著进展，这引发了用于对其进行分类和命名的标准的演变。本文综述了存在于血管平滑肌、内皮和血管周围神经元上的不同5-HT受体类型的分布和功能，并探讨了使用传统药理学方法对它们进行明确界定和区分的方式。还从当前关于5-HT受体分类的生化和分子角度考虑了每种受体类型的特征。
