Remy-Jardin M, Remy J, Cortet B, Mauri F, Delcambre B
Department of Radiology, Hôpital Calmette, Lille, France.
Radiology. 1994 Nov;193(2):375-82. doi: 10.1148/radiology.193.2.7972746.
To evaluate lung changes in rheumatoid arthritis (RA).
The authors reviewed the computed tomographic (CT) scans from 84 patients with RA with a mean articular disease duration (+/- standard deviation) of 12 years +/- 8 (range, 0.3-45 years). Fifteen patients underwent sequential CT evaluation during 5-65-month follow-up (mean, 18 months).
Thirty-eight patients (49%) had abnormal CT scans showing the following abnormalities: (a) bronchiectasis and/or bronchiolectasis (n = 23, 30%), (b) pulmonary nodules (n = 17, 22%), (c) subpleural micronodules and/or pseudoplaques (n = 13, 17%), (d) nonseptal linear attenuation (n = 14, 18%), (e) areas of ground-glass attenuation (n = 11, 14%), and (f) honeycombing (n = 8, 10%). Abnormal CT examinations were recorded in 11 of 38 asymptomatic patients (29%) and 27 of 39 symptomatic patients (69%). The following CT abnormalities were found with a significantly higher frequency among patients with respiratory symptoms: (a) bronchiectasis and/or bronchiolectasis, (b) rounded areas of attenuation, (c) areas of ground-glass attenuation, and (d) honeycombing.
CT may be a useful noninvasive tool for recognition of RA-associated lung disease with special emphasis on bronchial and bronchiolar changes.
评估类风湿关节炎（RA）患者的肺部变化。
作者回顾了84例RA患者的计算机断层扫描（CT）图像，这些患者的关节疾病平均病程（±标准差）为12年±8年（范围为0.3 - 45年）。15例患者在5 - 65个月的随访期（平均18个月）内接受了连续CT评估。
38例患者（49%）的CT扫描异常，表现为以下异常情况：（a）支气管扩张和/或细支气管扩张（n = 23，30%），（b）肺结节（n = 17，22%），（c）胸膜下微结节和/或假斑（n = 13，17%），（d）非间隔性线状密度减低（n = 14，18%），（e）磨玻璃样密度影区域（n = 11，14%），以及（f）蜂窝状改变（n = 8，10%）。38例无症状患者中有11例（29%）CT检查异常，39例有症状患者中有27例（69%）CT检查异常。在有呼吸道症状的患者中，以下CT异常的发生率明显更高：（a）支气管扩张和/或细支气管扩张，（b）圆形密度减低区，（c）磨玻璃样密度影区域，以及（d）蜂窝状改变。
CT可能是一种有用的非侵入性工具，用于识别与RA相关的肺部疾病，尤其应关注支气管和细支气管的变化。
