长期服用阿福司胆碱可对抗大鼠大脑中与年龄相关的微观解剖学变化。

Long term choline alfoscerate treatment counters age-dependent microanatomical changes in rat brain.

Amenta F, Ferrante F, Vega J A, Zaccheo D

Sezione di Anatomia Umana, Università di Camerino, Italy.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Sep;18(5):915-24. doi: 10.1016/0278-5846(94)90107-4.

Abstract

The density of nerve cells and of silver-gold impregnated fibres were evaluated in the hippocampus and in the cerebellar cortex in adult (12-month-old) and old (24-month-old) Sprague-Dawley rats. 2. The effects of long-term choline alfoscerate (GFC) treatment (100 mg/Kg/day for 6 months) on the above parameters were investigated in old rats. 3. The number of nerve cell profiles and the area occupied by silver-gold impregnated fibres were decreased both in the hippocampus and in the cerebellar cortex in old in comparison with adult rats. 4. GFC treatment countered the age-dependent reduction of nerve cells and silver-gold impregnated fibres. The hippocampus was more sensitive than the cerebellar cortex to the activity of GFC. 5. These results suggest that GFC treatment is effective in slowing down the expression of structural changes occurring in aging brain.

摘要

在成年（12个月大）和老年（24个月大）的斯普拉格-道利大鼠的海马体和小脑皮质中，评估神经细胞以及银金浸染纤维的密度。2. 在老年大鼠中研究了长期服用阿法甘油磷酸胆碱（GFC）（100毫克/千克/天，持续6个月）对上述参数的影响。3. 与成年大鼠相比，老年大鼠的海马体和小脑皮质中神经细胞轮廓的数量以及银金浸染纤维所占的面积均减少。4. GFC治疗对抗了神经细胞和银金浸染纤维随年龄增长的减少。海马体比小脑皮质对GFC的活性更敏感。5. 这些结果表明，GFC治疗在减缓衰老大脑中发生的结构变化的表达方面是有效的。