Sansores-García L, Majluf-Cruz A, Vargas-Vorácková F, Labardini-Méndez J
Departamento de Hematología, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
Rev Invest Clin. 1994 May-Jun;46(3):231-5.
Protein C (pC) is a natural-occurring anticoagulant and its acquired or hereditary deficiency has been associated with thrombosis. For its screening, technics that appraise both its plasmatic concentration and biological activity are used. The quantitative deficiency is important, but some characteristics of pC activity (pCA) suggest an essential role of the functional deficiency. Because reference levels have not been previously described in Mexico, we report here the results of a pCA assessed by a chromogenic assay in 88 adult healthy mexican people between 15 and 69 years of age. The pCA values at the 2.5 and 97.5% percentiles in our population were 75 and 137% in normal plasma. Functional disorders of this protein have been described in the presence of normal pC quantitative levels and, therefore, there are individuals with low pC concentrations and a normal pCA without thrombosis. These data suggest that the pCA could be a more important screening test than the quantitative determination as the first step in the study of a possible deficiency state of protein C.
蛋白C（pC）是一种天然存在的抗凝剂，其获得性或遗传性缺乏与血栓形成有关。对于其筛查，采用评估其血浆浓度和生物活性的技术。pC定量缺乏很重要，但pC活性（pCA）的一些特征表明功能缺乏起着关键作用。由于此前墨西哥尚未描述参考水平，我们在此报告了对88名年龄在15至69岁之间的墨西哥成年健康人群进行发色底物法评估pCA的结果。在我们的人群中，正常血浆中pCA值的第2.5和第97.5百分位数分别为75%和137%。在pC定量水平正常的情况下也已描述了该蛋白的功能紊乱，因此，存在pC浓度低但pCA正常且无血栓形成的个体。这些数据表明，作为研究蛋白C可能缺乏状态的第一步，pCA可能是比定量测定更重要的筛查试验。
