Rosenthal M S, Vogel G W
Emory University School of Medicine, Atlanta, Georgia.
Sleep. 1994 Jun;17(4):291-7. doi: 10.1093/sleep/17.4.291.
This study examined the effects of elevated ambient temperature (Ta) on body temperature (Tb) and rapid eye movement (REM) sleep in depressed and control rats. Previous studies have shown that elevations of Ta to the rat's thermoneutral zone of 29 degrees C produced an increase of REM sleep in control rats. In this study, 15 male Sprague-Dawley rats, seven saline control rats (SAL) and eight rats that were classified as depressed according to the chlorimipramine model of depression (CLI rats), were implanted for continuous Tb and polysomnographic recording and were exposed to two Ta's, 22 degrees C and 29 degrees C. CLI and SAL rats had significantly more REM sleep and a lower body temperature at 29 degrees C than at 22 degrees C. At 22 degrees C, CLI rats had significantly more REM sleep during the light period and a higher Tb in the light and dark periods than SAL control rats. At 29 degrees C, there were no significant differences in REM sleep or in Tb between CLI and SAL rats. Because human endogenous depression is associated with abnormal REM sleep and an elevated nocturnal Tb, these results give further support for the validity of the CLI model of depression and provide insight into the relationships among Tb, Ta, REM sleep and depression.
本研究考察了环境温度（Ta）升高对抑郁大鼠和对照大鼠体温（Tb）及快速眼动（REM）睡眠的影响。先前的研究表明，将Ta升高至大鼠29摄氏度的热中性区会使对照大鼠的REM睡眠增加。在本研究中，15只雄性斯普拉格-道利大鼠，7只生理盐水对照大鼠（SAL）和8只根据氯米帕明抑郁模型分类为抑郁的大鼠（CLI大鼠），被植入用于连续记录Tb和多导睡眠图，并暴露于22摄氏度和29摄氏度两种Ta环境中。CLI大鼠和SAL大鼠在29摄氏度时的REM睡眠明显多于22摄氏度时，且体温更低。在22摄氏度时，CLI大鼠在光照期的REM睡眠明显多于SAL对照大鼠，且在光照期和黑暗期的Tb更高。在29摄氏度时，CLI大鼠和SAL大鼠在REM睡眠或Tb方面无显著差异。由于人类内源性抑郁与异常的REM睡眠和夜间Tb升高有关，这些结果进一步支持了CLI抑郁模型的有效性，并为Tb、Ta、REM睡眠和抑郁之间的关系提供了见解。
